Journal article
Younger siblings, C-reactive protein, and risk of age-related macular degeneration
AC Cohn, L Busija, LD Robman, PN Dimitrov, M Varsamidis, LL Lim, PN Baird, RH Guymer
American Journal of Epidemiology | OXFORD UNIV PRESS INC | Published : 2013
DOI: 10.1093/aje/kws332
Abstract
In this study, we examined the relationship between exposure to siblings and 1) the risk of age-related macular degeneration (AMD) and 2) C-reactive protein levels. We retrospectively analyzed pooled cross-sectional data from 2 studies: the Cardiovascular Health and Age-Related Maculopathy Study (2001-2002) and the Age-Related Maculopathy Statin Study (2004-2006). Associations between number of siblings and AMD were assessed by using multinomial logistic regression. Associations between number of siblings and C-reactive protein levels were examined by using a generalized linear model for γ distribution. A higher number of younger siblings was associated with significantly lower odds of early..
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Grants
Awarded by Australian National Health and Medical Research Council
Awarded by NHMRC Practitioner Fellowship
Awarded by NHMRC Senior Research Fellowship
Awarded by NHMRC Centre for Research Excellence
Funding Acknowledgements
Data on siblings and covariates were collected in the course of 2 studies supported by the Australian National Health and Medical Research Council (grants 128201 and 350224). Additional support for these studies was provided by the Ramaciotti Foundation, the Hugh D. Williamson Foundation, the Lions Clubs of Victoria, the Ian Potter Foundation, and the John Reid Charitable Trust. Personnel support was provided through a NHMRC Practitioner Fellowship 529905 (R.H.G.), a NHMRC Senior Research Fellowship 1028444 (P.N.B.), an Eye Foundation/Novartis Medical Retina Fellowship (A.C.C.), and a postdoctoral fellowship jointly funded by the Melbourne Centre for Epidemiology, Biostatistics, and Health Services Research and the Centre for Research Excellence in Translational Neuroscience (L.B.). The Centre for Eye Research Australia is a recipient of a NHMRC Centre for Research Excellence grant (1001216) and the Australian National Health and Medical Research Council grant (529923) for the Centre for Clinical Research Excellence and Operational Infrastructure Support from the Victorian Government.